When the body experiences a stressor, such as an injury, illness, or trauma, the immune system, nervous system, and endocrine system all work together to defend against threat and bring the body back into homeostasis. These three systems are interdependent and act as one supersystem, so anything that affects one will affect all three.

This means that healing the nervous system will naturally bring both the immune system and the endocrine system back into balance and vice versa. It is also why persistent pain often progresses into autoimmune and/or endocrine disorders, and why these conditions can be so difficult to manage.